Sulfated oligosaccharide of Gracilaria lemaneiformis protect against food allergic response in mice by up-regulating immunosuppression.
Identifieur interne : 000026 ( Main/Exploration ); précédent : 000025; suivant : 000027Sulfated oligosaccharide of Gracilaria lemaneiformis protect against food allergic response in mice by up-regulating immunosuppression.
Auteurs : Qingmei Liu [République populaire de Chine] ; Yafen Zhang [République populaire de Chine] ; Zhendan Shu [République populaire de Chine] ; Meng Liu [République populaire de Chine] ; Runying Zeng [République populaire de Chine] ; Yanbo Wang [République populaire de Chine] ; Hong Liu [République populaire de Chine] ; Minjie Cao [République populaire de Chine] ; Wenjin Su [République populaire de Chine] ; Guangming Liu [République populaire de Chine]Source :
- Carbohydrate polymers [ 1879-1344 ] ; 2020.
Descripteurs français
- KwdFr :
- Agents protecteurs (composition chimique), Agents protecteurs (pharmacologie), Animaux (MeSH), Antiallergiques (composition chimique), Antiallergiques (pharmacologie), Cytokines (métabolisme), Gracilaria (composition chimique), Humains (MeSH), Hypersensibilité alimentaire (immunologie), Hypersensibilité alimentaire (prévention et contrôle), Hypersensibilité alimentaire (traitement médicamenteux), Immunosuppression thérapeutique (MeSH), Lymphocytes T régulateurs (effets des médicaments et des substances chimiques), Lymphocytes T régulateurs (immunologie), Lymphocytes auxiliaires Th2 (effets des médicaments et des substances chimiques), Lymphocytes auxiliaires Th2 (immunologie), Mastocytes (effets des médicaments et des substances chimiques), Modèles animaux de maladie humaine (MeSH), Oligosaccharides (composition chimique), Oligosaccharides (immunologie), Oligosaccharides (pharmacologie), Souris (MeSH), Sulfates (composition chimique).
- MESH :
- composition chimique : Agents protecteurs, Antiallergiques, Gracilaria, Oligosaccharides, Sulfates.
- effets des médicaments et des substances chimiques : Lymphocytes T régulateurs, Lymphocytes auxiliaires Th2, Mastocytes.
- immunologie : Hypersensibilité alimentaire, Lymphocytes T régulateurs, Lymphocytes auxiliaires Th2, Oligosaccharides.
- métabolisme : Cytokines.
- pharmacologie : Agents protecteurs, Antiallergiques, Oligosaccharides.
- prévention et contrôle : Hypersensibilité alimentaire.
- traitement médicamenteux : Hypersensibilité alimentaire.
- Animaux, Humains, Immunosuppression thérapeutique, Modèles animaux de maladie humaine, Souris.
English descriptors
- KwdEn :
- Animals (MeSH), Anti-Allergic Agents (chemistry), Anti-Allergic Agents (pharmacology), Cytokines (metabolism), Disease Models, Animal (MeSH), Food Hypersensitivity (drug therapy), Food Hypersensitivity (immunology), Food Hypersensitivity (prevention & control), Gracilaria (chemistry), Humans (MeSH), Immunosuppression (MeSH), Mast Cells (drug effects), Mice (MeSH), Oligosaccharides (chemistry), Oligosaccharides (immunology), Oligosaccharides (pharmacology), Protective Agents (chemistry), Protective Agents (pharmacology), Sulfates (chemistry), T-Lymphocytes, Regulatory (drug effects), T-Lymphocytes, Regulatory (immunology), Th2 Cells (drug effects), Th2 Cells (immunology).
- MESH :
- chemical , chemistry : Anti-Allergic Agents, Oligosaccharides, Protective Agents, Sulfates.
- chemical , immunology : Oligosaccharides.
- chemical , metabolism : Cytokines.
- chemical , pharmacology : Anti-Allergic Agents, Oligosaccharides, Protective Agents.
- chemistry : Gracilaria.
- drug effects : Mast Cells, T-Lymphocytes, Regulatory, Th2 Cells.
- drug therapy : Food Hypersensitivity.
- immunology : Food Hypersensitivity, T-Lymphocytes, Regulatory, Th2 Cells.
- prevention & control : Food Hypersensitivity.
- Animals, Disease Models, Animal, Humans, Immunosuppression, Mice.
Abstract
Sulfated oligosaccharide of Gracilaria lemaneiformis (GLSO) was prepared from sulfated polysaccharides which possessed antiallergic activity by degradation with high temperature and pressure combined with vitamin C treatment. The present study demonstrated that GLSO could attenuate food anaphylaxis, and inhibit the production of immunoglobulin E, histamine, and related cytokines in both prevention and therapy ovalbumin-induced mice model. Additionally, the gut microbiota analysis revealed that GLSO markedly rescued OVA-induced changes in the Firmicutes to Bacteroidetes ratio. Following flow cytometry, GLSO was found to suppress the subpopulation of T helper 2 and B cells, and significantly up-regulate regulatory T cells (Tregs) differentiation. Furthermore, GLSO-mediated immunosuppression could be verified by co-culturing Tregs sorted from GLSO-treated mice and CD4+ T cells or mast cells. In a word, GLSO attenuated food anaphylaxis through the regulation of gut microbiota and induction of immunosuppression. GLSO had the potential to be used as a nutrient component against food allergy.
DOI: 10.1016/j.carbpol.2019.115567
PubMed: 31887913
Affiliations:
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Fujian Provincial Engineering Technology Research Center of Marine Functional Food, Fujian Collaborative Innovation Center for Exploitation and Utilization of Marine Biological Resources, Jimei University, 43 Yindou Road, Xiamen, 361021, Fujian</wicri:regionArea><wicri:noRegion>Fujian</wicri:noRegion></affiliation></author><author><name sortKey="Zeng, Runying" sort="Zeng, Runying" uniqKey="Zeng R" first="Runying" last="Zeng">Runying Zeng</name><affiliation wicri:level="1"><nlm:affiliation>Third Institute of Oceanography, Ministry of Natural Resources, Daxue Road, Xiamen, 361005, Fujian, PR China.</nlm:affiliation><country xml:lang="fr">République populaire de Chine</country><wicri:regionArea>Third Institute of Oceanography, Ministry of Natural Resources, Daxue Road, Xiamen, 361005, Fujian</wicri:regionArea><wicri:noRegion>Fujian</wicri:noRegion></affiliation></author><author><name sortKey="Wang, Yanbo" sort="Wang, Yanbo" uniqKey="Wang Y" first="Yanbo" last="Wang">Yanbo Wang</name><affiliation wicri:level="3"><nlm:affiliation>College of Food and Biological Engineering, Xiamen Key Laboratory of Marine Functional Food, Fujian Provincial Engineering Technology Research Center of Marine Functional Food, Fujian Collaborative Innovation Center for Exploitation and Utilization of Marine Biological Resources, Jimei University, 43 Yindou Road, Xiamen, 361021, Fujian, PR China; Food Safety Key Laboratory of Zhejiang Province, School of Food Science and Biotechnology, Zhejiang Engineering Institute of Food Quality and Safety, Zhejiang Gongshang University, Hangzhou, PR China.</nlm:affiliation><country xml:lang="fr">République populaire de Chine</country><wicri:regionArea>College of Food and Biological Engineering, Xiamen Key Laboratory of Marine Functional Food, Fujian Provincial Engineering Technology Research Center of Marine Functional Food, Fujian Collaborative Innovation Center for Exploitation and Utilization of Marine Biological Resources, Jimei University, 43 Yindou Road, Xiamen, 361021, Fujian, PR China; Food Safety Key Laboratory of Zhejiang Province, School of Food Science and Biotechnology, Zhejiang Engineering Institute of Food Quality and Safety, Zhejiang Gongshang University, Hangzhou</wicri:regionArea><placeName><settlement type="city">Hangzhou</settlement><region type="province">Zhejiang</region></placeName></affiliation></author><author><name sortKey="Liu, Hong" sort="Liu, Hong" uniqKey="Liu H" first="Hong" last="Liu">Hong Liu</name><affiliation wicri:level="1"><nlm:affiliation>College of Food and Biological Engineering, Xiamen Key Laboratory of Marine Functional Food, Fujian Provincial Engineering Technology Research Center of Marine Functional Food, Fujian Collaborative Innovation Center for Exploitation and Utilization of Marine Biological Resources, Jimei University, 43 Yindou Road, Xiamen, 361021, Fujian, PR China.</nlm:affiliation><country xml:lang="fr">République populaire de Chine</country><wicri:regionArea>College of Food and Biological Engineering, Xiamen Key Laboratory of Marine Functional Food, Fujian Provincial Engineering Technology Research Center of Marine Functional Food, Fujian Collaborative Innovation Center for Exploitation and Utilization of Marine Biological Resources, Jimei University, 43 Yindou Road, Xiamen, 361021, Fujian</wicri:regionArea><wicri:noRegion>Fujian</wicri:noRegion></affiliation></author><author><name sortKey="Cao, Minjie" sort="Cao, Minjie" uniqKey="Cao M" first="Minjie" last="Cao">Minjie Cao</name><affiliation wicri:level="1"><nlm:affiliation>College of Food and Biological Engineering, Xiamen Key Laboratory of Marine Functional Food, Fujian Provincial Engineering Technology Research Center of Marine Functional Food, Fujian Collaborative Innovation Center for Exploitation and Utilization of Marine Biological Resources, Jimei University, 43 Yindou Road, Xiamen, 361021, Fujian, PR China.</nlm:affiliation><country xml:lang="fr">République populaire de Chine</country><wicri:regionArea>College of Food and Biological Engineering, Xiamen Key Laboratory of Marine Functional Food, Fujian Provincial Engineering Technology Research Center of Marine Functional Food, Fujian Collaborative Innovation Center for Exploitation and Utilization of Marine Biological Resources, Jimei University, 43 Yindou Road, Xiamen, 361021, Fujian</wicri:regionArea><wicri:noRegion>Fujian</wicri:noRegion></affiliation></author><author><name sortKey="Su, Wenjin" sort="Su, Wenjin" uniqKey="Su W" first="Wenjin" last="Su">Wenjin Su</name><affiliation wicri:level="1"><nlm:affiliation>College of Food and Biological Engineering, Xiamen Key Laboratory of Marine Functional Food, Fujian Provincial Engineering Technology Research Center of Marine Functional Food, Fujian Collaborative Innovation Center for Exploitation and Utilization of Marine Biological Resources, Jimei University, 43 Yindou Road, Xiamen, 361021, Fujian, PR China.</nlm:affiliation><country xml:lang="fr">République populaire de Chine</country><wicri:regionArea>College of Food and Biological Engineering, Xiamen Key Laboratory of Marine Functional Food, Fujian Provincial Engineering Technology Research Center of Marine Functional Food, Fujian Collaborative Innovation Center for Exploitation and Utilization of Marine Biological Resources, Jimei University, 43 Yindou Road, Xiamen, 361021, Fujian</wicri:regionArea><wicri:noRegion>Fujian</wicri:noRegion></affiliation></author><author><name sortKey="Liu, Guangming" sort="Liu, Guangming" uniqKey="Liu G" first="Guangming" last="Liu">Guangming Liu</name><affiliation wicri:level="1"><nlm:affiliation>College of Food and Biological Engineering, Xiamen Key Laboratory of Marine Functional Food, Fujian Provincial Engineering Technology Research Center of Marine Functional Food, Fujian Collaborative Innovation Center for Exploitation and Utilization of Marine Biological Resources, Jimei University, 43 Yindou Road, Xiamen, 361021, Fujian, PR China. Electronic address: liugmo@sina.com.</nlm:affiliation><country xml:lang="fr">République populaire de Chine</country><wicri:regionArea>College of Food and Biological Engineering, Xiamen Key Laboratory of Marine Functional Food, Fujian Provincial Engineering Technology Research Center of Marine Functional Food, Fujian Collaborative Innovation Center for Exploitation and Utilization of Marine Biological Resources, Jimei University, 43 Yindou Road, Xiamen, 361021, Fujian</wicri:regionArea><wicri:noRegion>Fujian</wicri:noRegion></affiliation></author></titleStmt><publicationStmt><idno type="wicri:source">PubMed</idno><date when="2020">2020</date><idno type="RBID">pubmed:31887913</idno><idno type="pmid">31887913</idno><idno type="doi">10.1016/j.carbpol.2019.115567</idno><idno type="wicri:Area/Main/Corpus">000110</idno><idno type="wicri:explorRef" wicri:stream="Main" wicri:step="Corpus" wicri:corpus="PubMed">000110</idno><idno type="wicri:Area/Main/Curation">000110</idno><idno type="wicri:explorRef" wicri:stream="Main" wicri:step="Curation">000110</idno><idno type="wicri:Area/Main/Exploration">000110</idno></publicationStmt><sourceDesc><biblStruct><analytic><title xml:lang="en">Sulfated oligosaccharide of Gracilaria lemaneiformis protect against food allergic response in mice by up-regulating immunosuppression.</title><author><name sortKey="Liu, Qingmei" sort="Liu, Qingmei" uniqKey="Liu Q" first="Qingmei" last="Liu">Qingmei Liu</name><affiliation wicri:level="1"><nlm:affiliation>College of Food and Biological Engineering, Xiamen Key Laboratory of Marine Functional Food, Fujian Provincial Engineering Technology Research Center of Marine Functional Food, Fujian Collaborative Innovation Center for Exploitation and Utilization of Marine Biological Resources, Jimei University, 43 Yindou Road, Xiamen, 361021, Fujian, PR China.</nlm:affiliation><country xml:lang="fr">République populaire de Chine</country><wicri:regionArea>College of Food and Biological Engineering, Xiamen Key Laboratory of Marine Functional Food, Fujian Provincial Engineering Technology Research Center of Marine Functional Food, Fujian Collaborative Innovation Center for Exploitation and Utilization of Marine Biological Resources, Jimei University, 43 Yindou Road, Xiamen, 361021, Fujian</wicri:regionArea><wicri:noRegion>Fujian</wicri:noRegion></affiliation></author><author><name sortKey="Zhang, Yafen" sort="Zhang, Yafen" uniqKey="Zhang Y" first="Yafen" last="Zhang">Yafen Zhang</name><affiliation wicri:level="1"><nlm:affiliation>College of Food and Biological Engineering, Xiamen Key Laboratory of Marine Functional Food, Fujian Provincial Engineering Technology Research Center of Marine Functional Food, Fujian Collaborative Innovation Center for Exploitation and Utilization of Marine Biological Resources, Jimei University, 43 Yindou Road, Xiamen, 361021, Fujian, PR China.</nlm:affiliation><country xml:lang="fr">République populaire de Chine</country><wicri:regionArea>College of Food and Biological Engineering, Xiamen Key Laboratory of Marine Functional Food, Fujian Provincial Engineering Technology Research Center of Marine Functional Food, Fujian Collaborative Innovation Center for Exploitation and Utilization of Marine Biological Resources, Jimei University, 43 Yindou Road, Xiamen, 361021, Fujian</wicri:regionArea><wicri:noRegion>Fujian</wicri:noRegion></affiliation></author><author><name sortKey="Shu, Zhendan" sort="Shu, Zhendan" uniqKey="Shu Z" first="Zhendan" last="Shu">Zhendan Shu</name><affiliation wicri:level="1"><nlm:affiliation>College of Food and Biological Engineering, Xiamen Key Laboratory of Marine Functional Food, Fujian Provincial Engineering Technology Research Center of Marine Functional Food, Fujian Collaborative Innovation Center for Exploitation and Utilization of Marine Biological Resources, Jimei University, 43 Yindou Road, Xiamen, 361021, Fujian, PR China.</nlm:affiliation><country xml:lang="fr">République populaire de Chine</country><wicri:regionArea>College of Food and Biological Engineering, Xiamen Key Laboratory of Marine Functional Food, Fujian Provincial Engineering Technology Research Center of Marine Functional Food, Fujian Collaborative Innovation Center for Exploitation and Utilization of Marine Biological Resources, Jimei University, 43 Yindou Road, Xiamen, 361021, Fujian</wicri:regionArea><wicri:noRegion>Fujian</wicri:noRegion></affiliation></author><author><name sortKey="Liu, Meng" sort="Liu, Meng" uniqKey="Liu M" first="Meng" last="Liu">Meng Liu</name><affiliation wicri:level="1"><nlm:affiliation>College of Food and Biological Engineering, Xiamen Key Laboratory of Marine Functional Food, Fujian Provincial Engineering Technology Research Center of Marine Functional Food, Fujian Collaborative Innovation Center for Exploitation and Utilization of Marine Biological Resources, Jimei University, 43 Yindou Road, Xiamen, 361021, Fujian, PR China.</nlm:affiliation><country xml:lang="fr">République populaire de Chine</country><wicri:regionArea>College of Food and Biological Engineering, Xiamen Key Laboratory of Marine Functional Food, Fujian Provincial Engineering Technology Research Center of Marine Functional Food, Fujian Collaborative Innovation Center for Exploitation and Utilization of Marine Biological Resources, Jimei University, 43 Yindou Road, Xiamen, 361021, Fujian</wicri:regionArea><wicri:noRegion>Fujian</wicri:noRegion></affiliation></author><author><name sortKey="Zeng, Runying" sort="Zeng, Runying" uniqKey="Zeng R" first="Runying" last="Zeng">Runying Zeng</name><affiliation wicri:level="1"><nlm:affiliation>Third Institute of Oceanography, Ministry of Natural Resources, Daxue Road, Xiamen, 361005, Fujian, PR China.</nlm:affiliation><country xml:lang="fr">République populaire de Chine</country><wicri:regionArea>Third Institute of Oceanography, Ministry of Natural Resources, Daxue Road, Xiamen, 361005, Fujian</wicri:regionArea><wicri:noRegion>Fujian</wicri:noRegion></affiliation></author><author><name sortKey="Wang, Yanbo" sort="Wang, Yanbo" uniqKey="Wang Y" first="Yanbo" last="Wang">Yanbo Wang</name><affiliation wicri:level="3"><nlm:affiliation>College of Food and Biological Engineering, Xiamen Key Laboratory of Marine Functional Food, Fujian Provincial Engineering Technology Research Center of Marine Functional Food, Fujian Collaborative Innovation Center for Exploitation and Utilization of Marine Biological Resources, Jimei University, 43 Yindou Road, Xiamen, 361021, Fujian, PR China; Food Safety Key Laboratory of Zhejiang Province, School of Food Science and Biotechnology, Zhejiang Engineering Institute of Food Quality and Safety, Zhejiang Gongshang University, Hangzhou, PR China.</nlm:affiliation><country xml:lang="fr">République populaire de Chine</country><wicri:regionArea>College of Food and Biological Engineering, Xiamen Key Laboratory of Marine Functional Food, Fujian Provincial Engineering Technology Research Center of Marine Functional Food, Fujian Collaborative Innovation Center for Exploitation and Utilization of Marine Biological Resources, Jimei University, 43 Yindou Road, Xiamen, 361021, Fujian, PR China; Food Safety Key Laboratory of Zhejiang Province, School of Food Science and Biotechnology, Zhejiang Engineering Institute of Food Quality and Safety, Zhejiang Gongshang University, Hangzhou</wicri:regionArea><placeName><settlement type="city">Hangzhou</settlement><region type="province">Zhejiang</region></placeName></affiliation></author><author><name sortKey="Liu, Hong" sort="Liu, Hong" uniqKey="Liu H" first="Hong" last="Liu">Hong Liu</name><affiliation wicri:level="1"><nlm:affiliation>College of Food and Biological Engineering, Xiamen Key Laboratory of Marine Functional Food, Fujian Provincial Engineering Technology Research Center of Marine Functional Food, Fujian Collaborative Innovation Center for Exploitation and Utilization of Marine Biological Resources, Jimei University, 43 Yindou Road, Xiamen, 361021, Fujian, PR China.</nlm:affiliation><country xml:lang="fr">République populaire de Chine</country><wicri:regionArea>College of Food and Biological Engineering, Xiamen Key Laboratory of Marine Functional Food, Fujian Provincial Engineering Technology Research Center of Marine Functional Food, Fujian Collaborative Innovation Center for Exploitation and Utilization of Marine Biological Resources, Jimei University, 43 Yindou Road, Xiamen, 361021, Fujian</wicri:regionArea><wicri:noRegion>Fujian</wicri:noRegion></affiliation></author><author><name sortKey="Cao, Minjie" sort="Cao, Minjie" uniqKey="Cao M" first="Minjie" last="Cao">Minjie Cao</name><affiliation wicri:level="1"><nlm:affiliation>College of Food and Biological Engineering, Xiamen Key Laboratory of Marine Functional Food, Fujian Provincial Engineering Technology Research Center of Marine Functional Food, Fujian Collaborative Innovation Center for Exploitation and Utilization of Marine Biological Resources, Jimei University, 43 Yindou Road, Xiamen, 361021, Fujian, PR China.</nlm:affiliation><country xml:lang="fr">République populaire de Chine</country><wicri:regionArea>College of Food and Biological Engineering, Xiamen Key Laboratory of Marine Functional Food, Fujian Provincial Engineering Technology Research Center of Marine Functional Food, Fujian Collaborative Innovation Center for Exploitation and Utilization of Marine Biological Resources, Jimei University, 43 Yindou Road, Xiamen, 361021, Fujian</wicri:regionArea><wicri:noRegion>Fujian</wicri:noRegion></affiliation></author><author><name sortKey="Su, Wenjin" sort="Su, Wenjin" uniqKey="Su W" first="Wenjin" last="Su">Wenjin Su</name><affiliation wicri:level="1"><nlm:affiliation>College of Food and Biological Engineering, Xiamen Key Laboratory of Marine Functional Food, Fujian Provincial Engineering Technology Research Center of Marine Functional Food, Fujian Collaborative Innovation Center for Exploitation and Utilization of Marine Biological Resources, Jimei University, 43 Yindou Road, Xiamen, 361021, Fujian, PR China.</nlm:affiliation><country xml:lang="fr">République populaire de Chine</country><wicri:regionArea>College of Food and Biological Engineering, Xiamen Key Laboratory of Marine Functional Food, Fujian Provincial Engineering Technology Research Center of Marine Functional Food, Fujian Collaborative Innovation Center for Exploitation and Utilization of Marine Biological Resources, Jimei University, 43 Yindou Road, Xiamen, 361021, Fujian</wicri:regionArea><wicri:noRegion>Fujian</wicri:noRegion></affiliation></author><author><name sortKey="Liu, Guangming" sort="Liu, Guangming" uniqKey="Liu G" first="Guangming" last="Liu">Guangming Liu</name><affiliation wicri:level="1"><nlm:affiliation>College of Food and Biological Engineering, Xiamen Key Laboratory of Marine Functional Food, Fujian Provincial Engineering Technology Research Center of Marine Functional Food, Fujian Collaborative Innovation Center for Exploitation and Utilization of Marine Biological Resources, Jimei University, 43 Yindou Road, Xiamen, 361021, Fujian, PR China. Electronic address: liugmo@sina.com.</nlm:affiliation><country xml:lang="fr">République populaire de Chine</country><wicri:regionArea>College of Food and Biological Engineering, Xiamen Key Laboratory of Marine Functional Food, Fujian Provincial Engineering Technology Research Center of Marine Functional Food, Fujian Collaborative Innovation Center for Exploitation and Utilization of Marine Biological Resources, Jimei University, 43 Yindou Road, Xiamen, 361021, Fujian</wicri:regionArea><wicri:noRegion>Fujian</wicri:noRegion></affiliation></author></analytic><series><title level="j">Carbohydrate polymers</title><idno type="eISSN">1879-1344</idno><imprint><date when="2020" type="published">2020</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Animals (MeSH)</term><term>Anti-Allergic Agents (chemistry)</term><term>Anti-Allergic Agents (pharmacology)</term><term>Cytokines (metabolism)</term><term>Disease Models, Animal (MeSH)</term><term>Food Hypersensitivity (drug therapy)</term><term>Food Hypersensitivity (immunology)</term><term>Food Hypersensitivity (prevention & control)</term><term>Gracilaria (chemistry)</term><term>Humans (MeSH)</term><term>Immunosuppression (MeSH)</term><term>Mast Cells (drug effects)</term><term>Mice (MeSH)</term><term>Oligosaccharides (chemistry)</term><term>Oligosaccharides (immunology)</term><term>Oligosaccharides (pharmacology)</term><term>Protective Agents (chemistry)</term><term>Protective Agents (pharmacology)</term><term>Sulfates (chemistry)</term><term>T-Lymphocytes, Regulatory (drug effects)</term><term>T-Lymphocytes, Regulatory (immunology)</term><term>Th2 Cells (drug effects)</term><term>Th2 Cells (immunology)</term></keywords><keywords scheme="KwdFr" xml:lang="fr"><term>Agents protecteurs (composition chimique)</term><term>Agents protecteurs (pharmacologie)</term><term>Animaux (MeSH)</term><term>Antiallergiques (composition chimique)</term><term>Antiallergiques (pharmacologie)</term><term>Cytokines (métabolisme)</term><term>Gracilaria (composition chimique)</term><term>Humains (MeSH)</term><term>Hypersensibilité alimentaire (immunologie)</term><term>Hypersensibilité alimentaire (prévention et contrôle)</term><term>Hypersensibilité alimentaire (traitement médicamenteux)</term><term>Immunosuppression thérapeutique (MeSH)</term><term>Lymphocytes T régulateurs (effets des médicaments et des substances chimiques)</term><term>Lymphocytes T régulateurs (immunologie)</term><term>Lymphocytes auxiliaires Th2 (effets des médicaments et des substances chimiques)</term><term>Lymphocytes auxiliaires Th2 (immunologie)</term><term>Mastocytes (effets des médicaments et des substances chimiques)</term><term>Modèles animaux de maladie humaine (MeSH)</term><term>Oligosaccharides (composition chimique)</term><term>Oligosaccharides (immunologie)</term><term>Oligosaccharides (pharmacologie)</term><term>Souris (MeSH)</term><term>Sulfates (composition chimique)</term></keywords><keywords scheme="MESH" type="chemical" qualifier="chemistry" xml:lang="en"><term>Anti-Allergic Agents</term><term>Oligosaccharides</term><term>Protective Agents</term><term>Sulfates</term></keywords><keywords scheme="MESH" type="chemical" qualifier="immunology" xml:lang="en"><term>Oligosaccharides</term></keywords><keywords scheme="MESH" type="chemical" qualifier="metabolism" xml:lang="en"><term>Cytokines</term></keywords><keywords scheme="MESH" type="chemical" qualifier="pharmacology" xml:lang="en"><term>Anti-Allergic Agents</term><term>Oligosaccharides</term><term>Protective Agents</term></keywords><keywords scheme="MESH" qualifier="chemistry" xml:lang="en"><term>Gracilaria</term></keywords><keywords scheme="MESH" qualifier="composition chimique" xml:lang="fr"><term>Agents protecteurs</term><term>Antiallergiques</term><term>Gracilaria</term><term>Oligosaccharides</term><term>Sulfates</term></keywords><keywords scheme="MESH" qualifier="drug effects" xml:lang="en"><term>Mast Cells</term><term>T-Lymphocytes, Regulatory</term><term>Th2 Cells</term></keywords><keywords scheme="MESH" qualifier="drug therapy" xml:lang="en"><term>Food Hypersensitivity</term></keywords><keywords scheme="MESH" qualifier="effets des médicaments et des substances chimiques" xml:lang="fr"><term>Lymphocytes T régulateurs</term><term>Lymphocytes auxiliaires Th2</term><term>Mastocytes</term></keywords><keywords scheme="MESH" qualifier="immunologie" xml:lang="fr"><term>Hypersensibilité alimentaire</term><term>Lymphocytes T régulateurs</term><term>Lymphocytes auxiliaires Th2</term><term>Oligosaccharides</term></keywords><keywords scheme="MESH" qualifier="immunology" xml:lang="en"><term>Food Hypersensitivity</term><term>T-Lymphocytes, Regulatory</term><term>Th2 Cells</term></keywords><keywords scheme="MESH" qualifier="métabolisme" xml:lang="fr"><term>Cytokines</term></keywords><keywords scheme="MESH" qualifier="pharmacologie" xml:lang="fr"><term>Agents protecteurs</term><term>Antiallergiques</term><term>Oligosaccharides</term></keywords><keywords scheme="MESH" qualifier="prevention & control" xml:lang="en"><term>Food Hypersensitivity</term></keywords><keywords scheme="MESH" qualifier="prévention et contrôle" xml:lang="fr"><term>Hypersensibilité alimentaire</term></keywords><keywords scheme="MESH" qualifier="traitement médicamenteux" xml:lang="fr"><term>Hypersensibilité alimentaire</term></keywords><keywords scheme="MESH" xml:lang="en"><term>Animals</term><term>Disease Models, Animal</term><term>Humans</term><term>Immunosuppression</term><term>Mice</term></keywords><keywords scheme="MESH" xml:lang="fr"><term>Animaux</term><term>Humains</term><term>Immunosuppression thérapeutique</term><term>Modèles animaux de maladie humaine</term><term>Souris</term></keywords></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en">Sulfated oligosaccharide of Gracilaria lemaneiformis (GLSO) was prepared from sulfated polysaccharides which possessed antiallergic activity by degradation with high temperature and pressure combined with vitamin C treatment. The present study demonstrated that GLSO could attenuate food anaphylaxis, and inhibit the production of immunoglobulin E, histamine, and related cytokines in both prevention and therapy ovalbumin-induced mice model. Additionally, the gut microbiota analysis revealed that GLSO markedly rescued OVA-induced changes in the Firmicutes to Bacteroidetes ratio. Following flow cytometry, GLSO was found to suppress the subpopulation of T helper 2 and B cells, and significantly up-regulate regulatory T cells (Tregs) differentiation. Furthermore, GLSO-mediated immunosuppression could be verified by co-culturing Tregs sorted from GLSO-treated mice and CD4<sup>+</sup> T cells or mast cells. In a word, GLSO attenuated food anaphylaxis through the regulation of gut microbiota and induction of immunosuppression. GLSO had the potential to be used as a nutrient component against food allergy.</div></front></TEI><pubmed><MedlineCitation Status="MEDLINE" Owner="NLM"><PMID Version="1">31887913</PMID><DateCompleted><Year>2020</Year><Month>09</Month><Day>24</Day></DateCompleted><DateRevised><Year>2020</Year><Month>09</Month><Day>24</Day></DateRevised><Article PubModel="Print-Electronic"><Journal><ISSN IssnType="Electronic">1879-1344</ISSN><JournalIssue CitedMedium="Internet"><Volume>230</Volume><PubDate><Year>2020</Year><Month>Feb</Month><Day>15</Day></PubDate></JournalIssue><Title>Carbohydrate polymers</Title><ISOAbbreviation>Carbohydr Polym</ISOAbbreviation></Journal><ArticleTitle>Sulfated oligosaccharide of Gracilaria lemaneiformis protect against food allergic response in mice by up-regulating immunosuppression.</ArticleTitle><Pagination><MedlinePgn>115567</MedlinePgn></Pagination><ELocationID EIdType="pii" ValidYN="Y">S0144-8617(19)31235-4</ELocationID><ELocationID EIdType="doi" ValidYN="Y">10.1016/j.carbpol.2019.115567</ELocationID><Abstract><AbstractText>Sulfated oligosaccharide of Gracilaria lemaneiformis (GLSO) was prepared from sulfated polysaccharides which possessed antiallergic activity by degradation with high temperature and pressure combined with vitamin C treatment. The present study demonstrated that GLSO could attenuate food anaphylaxis, and inhibit the production of immunoglobulin E, histamine, and related cytokines in both prevention and therapy ovalbumin-induced mice model. Additionally, the gut microbiota analysis revealed that GLSO markedly rescued OVA-induced changes in the Firmicutes to Bacteroidetes ratio. Following flow cytometry, GLSO was found to suppress the subpopulation of T helper 2 and B cells, and significantly up-regulate regulatory T cells (Tregs) differentiation. Furthermore, GLSO-mediated immunosuppression could be verified by co-culturing Tregs sorted from GLSO-treated mice and CD4<sup>+</sup> T cells or mast cells. In a word, GLSO attenuated food anaphylaxis through the regulation of gut microbiota and induction of immunosuppression. GLSO had the potential to be used as a nutrient component against food allergy.</AbstractText><CopyrightInformation>Copyright © 2019 Elsevier Ltd. All rights reserved.</CopyrightInformation></Abstract><AuthorList CompleteYN="Y"><Author ValidYN="Y"><LastName>Liu</LastName><ForeName>Qingmei</ForeName><Initials>Q</Initials><AffiliationInfo><Affiliation>College of Food and Biological Engineering, Xiamen Key Laboratory of Marine Functional Food, Fujian Provincial Engineering Technology Research Center of Marine Functional Food, Fujian Collaborative Innovation Center for Exploitation and Utilization of Marine Biological Resources, Jimei University, 43 Yindou Road, Xiamen, 361021, Fujian, PR China.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Zhang</LastName><ForeName>Yafen</ForeName><Initials>Y</Initials><AffiliationInfo><Affiliation>College of Food and Biological Engineering, Xiamen Key Laboratory of Marine Functional Food, Fujian Provincial Engineering Technology Research Center of Marine Functional Food, Fujian Collaborative Innovation Center for Exploitation and Utilization of Marine Biological Resources, Jimei University, 43 Yindou Road, Xiamen, 361021, Fujian, PR China.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Shu</LastName><ForeName>Zhendan</ForeName><Initials>Z</Initials><AffiliationInfo><Affiliation>College of Food and Biological Engineering, Xiamen Key Laboratory of Marine Functional Food, Fujian Provincial Engineering Technology Research Center of Marine Functional Food, Fujian Collaborative Innovation Center for Exploitation and Utilization of Marine Biological Resources, Jimei University, 43 Yindou Road, Xiamen, 361021, Fujian, PR China.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Liu</LastName><ForeName>Meng</ForeName><Initials>M</Initials><AffiliationInfo><Affiliation>College of Food and Biological Engineering, Xiamen Key Laboratory of Marine Functional Food, Fujian Provincial Engineering Technology Research Center of Marine Functional Food, Fujian Collaborative Innovation Center for Exploitation and Utilization of Marine Biological Resources, Jimei University, 43 Yindou Road, Xiamen, 361021, Fujian, PR China.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Zeng</LastName><ForeName>Runying</ForeName><Initials>R</Initials><AffiliationInfo><Affiliation>Third Institute of Oceanography, Ministry of Natural Resources, Daxue Road, Xiamen, 361005, Fujian, PR China.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Wang</LastName><ForeName>Yanbo</ForeName><Initials>Y</Initials><AffiliationInfo><Affiliation>College of Food and Biological Engineering, Xiamen Key Laboratory of Marine Functional Food, Fujian Provincial Engineering Technology Research Center of Marine Functional Food, Fujian Collaborative Innovation Center for Exploitation and Utilization of Marine Biological Resources, Jimei University, 43 Yindou Road, Xiamen, 361021, Fujian, PR China; Food Safety Key Laboratory of Zhejiang Province, School of Food Science and Biotechnology, Zhejiang Engineering Institute of Food Quality and Safety, Zhejiang Gongshang University, Hangzhou, PR China.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Liu</LastName><ForeName>Hong</ForeName><Initials>H</Initials><AffiliationInfo><Affiliation>College of Food and Biological Engineering, Xiamen Key Laboratory of Marine Functional Food, Fujian Provincial Engineering Technology Research Center of Marine Functional Food, Fujian Collaborative Innovation Center for Exploitation and Utilization of Marine Biological Resources, Jimei University, 43 Yindou Road, Xiamen, 361021, Fujian, PR China.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Cao</LastName><ForeName>Minjie</ForeName><Initials>M</Initials><AffiliationInfo><Affiliation>College of Food and Biological Engineering, Xiamen Key Laboratory of Marine Functional Food, Fujian Provincial Engineering Technology Research Center of Marine Functional Food, Fujian Collaborative Innovation Center for Exploitation and Utilization of Marine Biological Resources, Jimei University, 43 Yindou Road, Xiamen, 361021, Fujian, PR China.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Su</LastName><ForeName>Wenjin</ForeName><Initials>W</Initials><AffiliationInfo><Affiliation>College of Food and Biological Engineering, Xiamen Key Laboratory of Marine Functional Food, Fujian Provincial Engineering Technology Research Center of Marine Functional Food, Fujian Collaborative Innovation Center for Exploitation and Utilization of Marine Biological Resources, Jimei University, 43 Yindou Road, Xiamen, 361021, Fujian, PR China.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Liu</LastName><ForeName>Guangming</ForeName><Initials>G</Initials><AffiliationInfo><Affiliation>College of Food and Biological Engineering, Xiamen Key Laboratory of Marine Functional Food, Fujian Provincial Engineering Technology Research Center of Marine Functional Food, Fujian Collaborative Innovation Center for Exploitation and Utilization of Marine Biological Resources, Jimei University, 43 Yindou Road, Xiamen, 361021, Fujian, PR China. Electronic address: liugmo@sina.com.</Affiliation></AffiliationInfo></Author></AuthorList><Language>eng</Language><PublicationTypeList><PublicationType UI="D016428">Journal Article</PublicationType></PublicationTypeList><ArticleDate DateType="Electronic"><Year>2019</Year><Month>11</Month><Day>06</Day></ArticleDate></Article><MedlineJournalInfo><Country>England</Country><MedlineTA>Carbohydr Polym</MedlineTA><NlmUniqueID>8307156</NlmUniqueID><ISSNLinking>0144-8617</ISSNLinking></MedlineJournalInfo><ChemicalList><Chemical><RegistryNumber>0</RegistryNumber><NameOfSubstance UI="D018926">Anti-Allergic Agents</NameOfSubstance></Chemical><Chemical><RegistryNumber>0</RegistryNumber><NameOfSubstance UI="D016207">Cytokines</NameOfSubstance></Chemical><Chemical><RegistryNumber>0</RegistryNumber><NameOfSubstance UI="D009844">Oligosaccharides</NameOfSubstance></Chemical><Chemical><RegistryNumber>0</RegistryNumber><NameOfSubstance UI="D020011">Protective Agents</NameOfSubstance></Chemical><Chemical><RegistryNumber>0</RegistryNumber><NameOfSubstance UI="D013431">Sulfates</NameOfSubstance></Chemical></ChemicalList><CitationSubset>IM</CitationSubset><MeshHeadingList><MeshHeading><DescriptorName UI="D000818" MajorTopicYN="N">Animals</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D018926" MajorTopicYN="N">Anti-Allergic Agents</DescriptorName><QualifierName UI="Q000737" MajorTopicYN="N">chemistry</QualifierName><QualifierName UI="Q000494" MajorTopicYN="Y">pharmacology</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D016207" MajorTopicYN="N">Cytokines</DescriptorName><QualifierName UI="Q000378" MajorTopicYN="N">metabolism</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D004195" MajorTopicYN="N">Disease Models, Animal</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D005512" MajorTopicYN="N">Food Hypersensitivity</DescriptorName><QualifierName UI="Q000188" MajorTopicYN="Y">drug therapy</QualifierName><QualifierName UI="Q000276" MajorTopicYN="N">immunology</QualifierName><QualifierName UI="Q000517" MajorTopicYN="N">prevention & control</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D044724" MajorTopicYN="N">Gracilaria</DescriptorName><QualifierName UI="Q000737" MajorTopicYN="Y">chemistry</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D006801" MajorTopicYN="N">Humans</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D007165" MajorTopicYN="N">Immunosuppression</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D008407" MajorTopicYN="N">Mast Cells</DescriptorName><QualifierName UI="Q000187" MajorTopicYN="N">drug effects</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D051379" MajorTopicYN="N">Mice</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D009844" MajorTopicYN="N">Oligosaccharides</DescriptorName><QualifierName UI="Q000737" MajorTopicYN="N">chemistry</QualifierName><QualifierName UI="Q000276" MajorTopicYN="N">immunology</QualifierName><QualifierName UI="Q000494" MajorTopicYN="Y">pharmacology</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D020011" MajorTopicYN="N">Protective Agents</DescriptorName><QualifierName UI="Q000737" MajorTopicYN="N">chemistry</QualifierName><QualifierName UI="Q000494" MajorTopicYN="Y">pharmacology</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D013431" MajorTopicYN="N">Sulfates</DescriptorName><QualifierName UI="Q000737" MajorTopicYN="N">chemistry</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D050378" MajorTopicYN="N">T-Lymphocytes, Regulatory</DescriptorName><QualifierName UI="Q000187" MajorTopicYN="N">drug effects</QualifierName><QualifierName UI="Q000276" MajorTopicYN="N">immunology</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D018418" MajorTopicYN="N">Th2 Cells</DescriptorName><QualifierName UI="Q000187" MajorTopicYN="N">drug effects</QualifierName><QualifierName UI="Q000276" MajorTopicYN="N">immunology</QualifierName></MeshHeading></MeshHeadingList><KeywordList Owner="NOTNLM"><Keyword MajorTopicYN="N">Anti-food allergy</Keyword><Keyword MajorTopicYN="N">Gut microbiota</Keyword><Keyword MajorTopicYN="N">Immunosuppression</Keyword><Keyword MajorTopicYN="N">Polysaccharide degradation</Keyword><Keyword MajorTopicYN="N">Regulatory T cells</Keyword><Keyword MajorTopicYN="N">Sulfated oligosaccharide of Gracilaria lemaneiformis</Keyword></KeywordList></MedlineCitation><PubmedData><History><PubMedPubDate PubStatus="received"><Year>2019</Year><Month>08</Month><Day>24</Day></PubMedPubDate><PubMedPubDate PubStatus="revised"><Year>2019</Year><Month>10</Month><Day>27</Day></PubMedPubDate><PubMedPubDate PubStatus="accepted"><Year>2019</Year><Month>11</Month><Day>01</Day></PubMedPubDate><PubMedPubDate PubStatus="entrez"><Year>2020</Year><Month>1</Month><Day>1</Day><Hour>6</Hour><Minute>0</Minute></PubMedPubDate><PubMedPubDate PubStatus="pubmed"><Year>2020</Year><Month>1</Month><Day>1</Day><Hour>6</Hour><Minute>0</Minute></PubMedPubDate><PubMedPubDate PubStatus="medline"><Year>2020</Year><Month>9</Month><Day>25</Day><Hour>6</Hour><Minute>0</Minute></PubMedPubDate></History><PublicationStatus>ppublish</PublicationStatus><ArticleIdList><ArticleId IdType="pubmed">31887913</ArticleId><ArticleId IdType="pii">S0144-8617(19)31235-4</ArticleId><ArticleId IdType="doi">10.1016/j.carbpol.2019.115567</ArticleId></ArticleIdList></PubmedData></pubmed><affiliations><list><country><li>République populaire de Chine</li></country><region><li>Zhejiang</li></region><settlement><li>Hangzhou</li></settlement></list><tree><country name="République populaire de Chine"><noRegion><name sortKey="Liu, Qingmei" sort="Liu, Qingmei" uniqKey="Liu Q" first="Qingmei" last="Liu">Qingmei Liu</name></noRegion><name sortKey="Cao, Minjie" sort="Cao, Minjie" uniqKey="Cao M" first="Minjie" last="Cao">Minjie Cao</name><name sortKey="Liu, Guangming" sort="Liu, Guangming" uniqKey="Liu G" first="Guangming" last="Liu">Guangming Liu</name><name sortKey="Liu, Hong" sort="Liu, Hong" uniqKey="Liu H" first="Hong" last="Liu">Hong Liu</name><name sortKey="Liu, Meng" sort="Liu, Meng" uniqKey="Liu M" first="Meng" last="Liu">Meng Liu</name><name sortKey="Shu, Zhendan" sort="Shu, Zhendan" uniqKey="Shu Z" first="Zhendan" last="Shu">Zhendan Shu</name><name sortKey="Su, Wenjin" sort="Su, Wenjin" uniqKey="Su W" first="Wenjin" last="Su">Wenjin Su</name><name sortKey="Wang, Yanbo" sort="Wang, Yanbo" uniqKey="Wang Y" first="Yanbo" last="Wang">Yanbo Wang</name><name sortKey="Zeng, Runying" sort="Zeng, Runying" uniqKey="Zeng R" first="Runying" last="Zeng">Runying Zeng</name><name sortKey="Zhang, Yafen" sort="Zhang, Yafen" uniqKey="Zhang Y" first="Yafen" last="Zhang">Yafen 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